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Before being treated with ALA (600 mg/day), patients received a standard 3-month course of treatment with a choline esterase inhibitor [129]
Another strategy to extend levodopa efficacy involves inhibiting catechol-O-methyltransferase, an enzyme responsible for both peripheral levodopa degradation and central dopamine breakdown
QiaoLLiYChiYJiYGaoYHwangHet al
