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Owing to their structural diversity and multi-target activities, they regulate interconnected pathways involved in inflammation, oxidative stress, and immune responses (Zhao et al., 2025
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MET has been shown to remain active post-endocytosis and furthermore to require endocytosis to sustain its activation and/or downstream signalling [3,4,5]
Besides prescribing drugs that can slow progression, doctors can offer a range of medications to treat ALS-related symptoms, including modafinil (Provigil) for fatigue, mexiletine for muscle cramps, gabapentin (Horizant) for chronic pain, antidepressants for depression, and dexmedetomidine (Precedex) for sleep disorders
