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Practical non-invasive methods include retrospective calculation of the iron removed based on the number and volume of therapeutic phlebotomies undertaken to reduce the serum ferritin level to 50100 g/L, based on a 500 mL phlebotomy removing approximately 250 mg of iron [51, 94], as well as magnetic resonance imaging

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The K D of Cu 2+ bound to A was determined to be at attomolar level (10 18 ), which could be removed from aggregated A in brains of AD mice in vivo by a Cu 2+ chelator (110) of known nanomolar (10 9 ) K D

Qiao W, Niu L, Jiang W, et al