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Hopwood J, Walker N, McDonagh L, et al

Therefore, the available literature on zonulin as a non-invasive marker for disease characterized by barrier dysfunction should be interpreted with extreme caution

In metabolomics, significant alterations were observed in metabolism related to arginine and proline, arachidonic acid, glutathione metabolism, and ubiquinone and other terpenoid-quinone biosynthesis pathways as CKD progressed with further metabolomic analyses revealing that variations in the distributions of pro-oxidant and toxic metabolites from the four identified metabolic pathways were observed in the feces and serum of the patients as the disease progressed