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Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells

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Aside from its role in catecholamine catabolism, COMT converts an antiestrogen compound (2-hydroxyestradiol) to a proestrogen (2-methoxyestradiol) and leads to an estrogen-rich environment

The liver serves as the central hub for LM, with mitochondria highly expressing the LKR/SDH enzyme complex, processing approximately 70% of dietary lysine