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The mechanisms by which inflammation affects tight junction structure and function and transcellular mechanisms such as endocytosis are largely unknown, although reproducible correlations have been observed between the severity of experimental and clinical disease and on the one hand and transepithelial electrical resistance, transport of paracellular markers, and systemic LPS concentrations and on the other [42, 86]

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Unexpectedly, despite the large amounts of ASD drained into the GI tract, only 0.011% of the parent drug was excreted in the feces within 48 h