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Furthermore, elevated glutathione synthesis in TLS in the kidney is reflected in urinary GSH concentration, suggesting the possibility of its clinical application as a novel biomarker to detect TLS in the kidney

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The ability of rutin to exert its neuroprotective effects in different models of NDs could be ascribed to its antioxidant as well as antiapoptotic and anti-inflammatory activities

In particular, mossy fiber sprouting in hippocampal dentate granule cells lowers the seizure threshold and contributes to cognitive and emotional impairments ( Aberrant elevation of inflammatory cytokinesparticularly IL-1 and TNF-represents a central pathological mechanism in EDC
