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Description
TTM pre-treatment reduces CuONPs-induced reactive oxygen species generation and NLRP3 activation, indicating that macrophage NLRP3-dependent pyroptosis requires copper involvement, and reducing copper availability can alleviate CuONPs-induced macrophage pyroptosis-mediated immunological damage (85).Recently, Dong et al

Bacterial products such as LPS, predominantly derived by gramnegative organisms, can activate microglia TLR4 [214, 215], enhancing syn uptake, oxidative stress, and cytokine productionall contributing to neurotoxicity [216, 217, 218]

Prodrome suggestive of infection

Primers 9, 62
