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The goal is the minimum effective dose, not the maximum tolerable dose
may be diffuse Rectal bleeding more common in colonic Crohns

According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, obese patients receiving incretin-based therapies for weight loss should be monitored for the development of pancreatitis
If CRP drops but fibrinogen stays high, dig deeper
