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For this reason we believe the most effective plasmid design should place Gpx closest to the promoter, where it has the highest probability of being fully transcribed by RNA polymerase, and GR furthest from the promoter, since high concentrations of GR appear to be less critical given its efficacy

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The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis