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Consistent with a role of the Leu allele in lung cancer risk, a casecontrol study of lung cancer from Korea found that individuals with at least one Leu allele had increased levels of urinary 8-hydroxydeoxyguanosine, the mutagenized DNA oxidation product compared to Pro/Pro (211), as well as a greater risk for lung cancer

It is of crucial importance in deuterating oxidative stress as well as free radicals in the body

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