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Mechanisms and clinical implications of human gut microbiota-drug interactions in the precision medicine era

When iron ions are overloaded, the iron ions entering the cell react with reactive oxygen species in the Fenton reaction, peroxidizing polyunsaturated fatty acids on the cell membrane and generating lipid peroxides, leading to damage of the cell membrane structure and eventually triggering cell death (Ivanov et al., 2013

DHA administration decreased serum NFL levels compared to placebo-treated athletes, but although the authors suggested that DHA supplementation is therefore neuroprotective, NFL was the only marker measured (108)

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