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Abdelgalil AA, Alkahtani HM, Al-Jenoobi FI

The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis

hence making it an ineffective treatment option

Mitochondrial GR is essential for: Protecting the electron transport chain components from oxidative damage Maintaining mitochondrial DNA integrity against oxidative lesions Supporting ATP production by preserving mitochondrial membrane potential Preventing mitochondrial-initiated apoptosis triggered by excessive oxidative stress Facilitating mitochondrial glutathione transport and utilization The mitochondrial glutathione system is particularly critical in neurons and other cells with high energy demands, where mitochondrial dysfunction can have catastrophic consequences