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In another embodiment, a PNA may be modified, for example to enhance its stability or cellular uptake, by: by attaching lipophilic or other ancillary groups to the PNA, by forming PNA-DNA chimeras, or by using liposomes or other drug delivery techniques known in the art

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Low-dose NTX (LDN) is taken in ME/CFS patients to treat pain attributable to insufficient opioid peptide secretion and excess release of pro-inflammatory cytokines, with 73.9% of patients reporting improved symptoms [198]