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In addition, SSd downregulates the expression of NF-B, upregulating fibroblast growth factor 2 (FGF2), a neurotrophic growth factor involved in regulating synaptic plasticity and neuronal growth (Chao et al., 2020)
Administration of general anesthetics might increase the level of ROS by elevating partial pressure of brain tissue oxygen of neonates, then disrupt cognitive functions in immature brains ( Well-balanced ROS and antioxidants is crucial to the proper development of the central nervous system
