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For instance, TEPP-46 and microbial metabolite-based therapies (e.g., butyrate, itaconate) exhibit robust efficacy in animal models but have yet to be systematically evaluated in human autoimmune populations
Kagiava A, Tsingotjidou A, Emmanouilides C, Theophilidis G
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[59] showed that both the amount and transcriptional activity of Nrf2 are reduced in aging rats
