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Neurons are particularly vulnerable to oxidative damage in the presence of OS and NS because of several factors involving, among others, the presence of large amounts of polyunsaturated fatty acids in their lipid bilayers, the high dependence on paramagnetic oxygen for neuronal survival, and the high metabolic rate of neurons and glia with attendant free radical leak from mitochondria (8)

Alpha Lipoic Acid Blend

doi: 10.1042/bj1700285

Alternatively, fumaric acid can be synthesized via chemical oxidation of benzene derivatives , though fermentation-based production is preferred for food and pharmaceutical applications due to its safety profile