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Br Food J 116:611628
REDEFINE-1: Phase 3 Pivotal Trial (NCT05064293) Study Title: "Efficacy and Safety of CagriSema in Adults With Overweight or Obesity (REDEFINE 1)" Status: Completed (Results Published 2024) Phase: Phase 3 Enrollment: 3,400+ participants Study Period: 2021-2024 Location: Global, 15+ countries Design: Randomized, double-blind, active-controlled Duration: 68 weeks Intervention: CagriSema (cagrilintide 2.4mg + semaglutide 2.4mg) vs
Two vials for Phase 2 is manageable
Conversely, the role of PKC in internalization was ruled out using activators of this kinase in the locus coeruleus neurons expressing the FLAG-tagged MOR (Arttamangkul et al., 2014)
