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Cardiovascular outcomes with ertugliflozin in type 2 diabetes

Still, in the process, it can create Superoxide, oxygen with too many electrons that is poisonous to everything around it, be it mitochondria, DNA, proteins, cell membranes, etc
However, clinical human trials are still limited

Phase 2 results at 48 weeks (Jastreboff et al., NEJM 2023): Phase 3 TRIUMPH-4 at 68 weeks (Lilly Press Release, Dec 2025): The 12 mg dose produced 28.7% body weight loss, an average of 71.2 lbs from a 248.5 lb baseline
