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Among the numerous partners that interact with NRF2 regulating its activity, two members of the CNC-bZIP protein family BTB and CNC homolog 1 (BACH1) and BTB and CNC homolog 2 (BACH2) are two negative regulators of NRF2: they compete with NRF2 for the binding to ARE sequences of target genes, thereby preventing the production of antioxidant enzymes and cellular defense against toxicity [232, 233]

[DOI] [PubMed] [Google Scholar] 104.Zhang M., Du H., Huang Z., Zhang P., Yue Y., Wang W., Liu W., Zeng J., Ma J., Chen G., et al

doi: 10.3390/antiox11061037 281 GrabarczykMJustyskaWCzpakowskaJSmoliskaEBieleninAGlabinskiAet al

Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription