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Cornick, N
We then asked if increased intracellular Cys availability could inhibit ferroptosis even in the absence of GPX4
The work of Zhang and colleagues demonstrated the accumulation of intracellular ROS and the subsequent activation of the NLRP3 inflammasome in macrophages from mice of the J774.1 line when the P2X7 receptor was activated (Zhang et al., 2021)
Accordingly, some interpretations should be considered as hypothesized or proposed mechanisms that require further empirical confirmation
