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DiNicolantonio, PharmD, Wegmans Pharmacy, Ithaca, NY, observes, "Although therapies for acute coronary syndrome (ACS), including percutaneous coronary intervention, dual antiplatelet therapy, b-blockers (BBs), statins, angiotensin-converting enzyme inhibitors (ACEIs), omega-3 fatty acids, and cardiac rehabilitation, have markedly improved clinical outcomes, adverse cardiovascular (CV) events still occur too frequently after ACS

8m), indicating increased denervation

Another mechanism, by which high intensity muscle contractions may exert toxic effect on skeletal muscle, is transient hypoxia

Barth SW, Lehner MD, Dietz GPH, Schulze H