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Due to its exceptionally low pKa of 6.7, Hcy-thiolactone remains mostly neutral in the blood and is primarily cleared by the kidneys (~1% is reabsorbed, and over 95% is excreted by the kidneys) [39]

Unlike the GLP-1 class of best peptides for weight loss, AOD-9604 does not suppress appetite

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There is no single published list of FDA-approved peptides, but the category of formally approved peptide-based drugs includes GLP-1 receptor agonists (Ozempic, Wegovy, Mounjaro, Zepbound), insulin analogues, leuprolide, vasopressin analogues, oxytocin, and several others used in endocrinology and oncology