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Evidence supports that IL-6 has an ability to suppress the enzymes iodothyronine deiodinases type I (D1) and II (D2), reducing the conversion of prohormone thyroxine T4 to its active form T3, which ensures the deregulation of glutamate cysteine ligase (GCL) and the successive reduction of GSH synthesis [72,73]
Noctor, Guillaume Queval, +2 authors Christine H
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