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The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene

KDM3A or KDM4C suppression resulted in robust DNA damage response and aggravated cellular senescence, whereas KDM3A or KDM4C overexpression promoted heterochromatin reorganization and decreased DNA damage response [106]

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In particular, methionine synthase (MS) catalyzes the remethylation of Hcy to Met using vitamin B12 (cobalamin) as a co-factor and 5-methyl THF as the methyl donor [9]