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Another study found that e-cigarette exposure enhanced airway dilation, mucus secretion and fibrogenesis in COPD mice, which was associated with an increased M2 macrophage phenotype (79)

Acknowledgments We would like to express our sincere gratitude to Samia El Alam for her careful and insightful review of the manuscript

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This study reported that the A1298C variant produced opposite effects compared to the C677T variant
