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Description
Dimethyl fumarate (DMF), an FDA-approved drug prescribed for the treatment of multiple sclerosis (55, 56), activates NRF2 by disrupting its interaction with KEAP1 ( Figure 7A ), allowing NRF2 to translocate to the nucleus and become transcriptionally active (5557)
In addition, ROS induces both the activation and synthesis of AP-1, a regulator of cell growth, proliferation, and apoptosis [138, 139] and transcription factors such as STAT3, HIF-1, and p53 [118, 140, 141]
Acta Paediatr
[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Ali SA, Bommaraju S, Patwa J, Khare P, Rachamalla M, Niyogi S, Datusalia AK
