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doi:10.1038/s41419-021-03998-w
Many were forced to discontinue therapy or seek alternatives
These reprogrammed M1-macrophages secrete IL-12, TNF-, and IFN-, further amplifying CD8 T-cell cytotoxic function and enhancing the efficacy of immune checkpoint blockade [112]
confirmed that nicotine exposure, a key product of cigarettes, triggered oxidative stress in pancreatic stellate cells via induction of the mitochondrial dynamics towards fission as shown by upregulation of Drp1 and smaller, fragmented-shaped mitochondria
