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Disrupted glucose metabolism in ADRD is closely linked with an inflammatory and neurotoxic milieu, as increased presence of ROS and pro-inflammatory cytokines reduce expression of glucose transporters, disrupt insulin signalling, and reduce mitochondrial efficiency and function, resulting in impaired transport, uptake, and metabolism of glucose (RojasGutierrez et al., 2017
RM ANOVAs indicated significant interactions of treatment x time during wakefulness (F 11,88 = 2.51, p = 0.009, 2 p = 0.24, Figure 3A) and NREMS (F 11,88 = 2.7, p = 0.005, 2 p = 0.25, Figure 3B)
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doi: 10.1016/S0140-6736(09)62124-3, 193
