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Description
Clomiphene citrate (CC) is the first line of treatment to induce ovulation, but it is futile in many patients, along with ovarian hyperstimulation syndrome (OHS) seen in 10% of cases [4]
For acute OIPN, the dysfunction of ion channels, OCT protein, and glial cells are involved in the acute pain, whereas the main mechanisms relevant to chronic OIPN are nuclear DNA damage, oxidative stress-induced mitochondrial damage, glia activation-related neuroinflammation, and gut microbiota-induced inflammation (Fig
see also section 6.2.2)
Repairing this intricate, high-stress network is a formidable challenge
