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Description
Animal models of depression show a decrease in cell proliferation (creation of new brain cells) as well as an increase in cell death (apoptosis).[ref] A relative lack of ATP due to mitochondrial dysfunction could also impact the ability of neurotransmitters to bind to their receptors

Shi, C., Li, Q

Components of the glutathione cycle as markers of biological age: An approach to clinical application in aging

Matrix degradation and more
