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The HPD gene is located on chromosome 12q24.31 which is composed of 17 exons that generate two alternatively spliced mRNAs encoding proteins of 393 amino acids (isoform 1) and 354 amino acids (isoform 2)

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Citric acid: a nexus between cellular mechanisms and biomaterial innovations

however, the maximal respiration measured following the injection of a mitochondrial uncoupling agent (carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone (FCCP)) decreased significantly in the H 2 O 2 -exposed group compared to the control group, while it was protected significantly in both the 0.1 nM and 1.0 nM PQQ-pretreated groups compared to the H 2 O 2 -exposed group (Fig