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Consequently, the authors propose that A1AT augmentation therapy should be considered and investigated as a potential treatment for COVID-19

While iron metabolism and lipid peroxidation trigger ferroptosis under pathological conditions, the precise mechanisms remain incompletely understood and warrant further investigation

To examine whether the therapeutic effect could be maintained after a suspension of treatment, administration of PEI or peptide was resumed and continued for 4 more months (experimental set 2, Appendix Fig S3)