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ALDH is a marker for both normal stem cells and CSCs and is an intracellular enzyme that converts retinol into retinoic acid, and detoxifies the cellular system [59]
Given the lack of change in cell densities, the observed tissue swelling is likely to be due to increased water content and oedema, which has been found to occur as early as 3 days into cuprizone exposure and continue to at least 5 weeks 58
To date, there is a lack of targeted and specific agent and regimen for the diagnosis and therapeutic of PF 5
