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phosphorylated CREB in turn drives transcription of the GH gene and helps sustain the somatotroph-specific transcription factor Pit-1

J Neurogastroenterol Motil 2017
and thus, it could indicate that low circulating levels of IGF-1 can lead to MetS and raise the risk for CVD and T2D

[DOI] [PubMed] [Google Scholar] van den Brink-van der Laan E, Killian JA, de Kruijff B
