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December 21, 2024

130 SIRT1 deacetylates NF-B, inhibiting pro-inflammatory cytokines (IL-6, TNF-) while promoting anti-inflammatory cytokines (IL-10), 35 limiting Th17 and Tc activation and supporting overall immune balance

While the details of the mechanisms involved need to be further investigated, these studies open the intriguing potential to use GABA treatment to re-generate beta cells in T1D [139]

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