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SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling

elegans , for both technical reasons, to circumvent the caveat of comparing different sterile strains with varying cellular constituents, and biological reasons, as the germline is known to communicate closely with the intestine to modulate metabolism and longevity

[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Alawi F

Cholesterol homeostasis is a complex dynamic equilibrium process composed of regulated pathways of biosynthesis, uptake, efflux and esterification, and it involves a complex web of enzymes, transport proteins, membrane-bound transcription factors and epigenetic modifications