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Recently, NNMT has been emerging as a new mechanism-of-action target for treatment of obesity and associated T2D [10]
In addition, in research on aging-related muscle atrophy (sarcopenia), it can promote muscle cell proliferation and differentiation, reduce muscle cell apoptosis, and enhance muscle strength and endurance by activating the SIRT1 signaling pathway

American journal of human genetics

Compared to rigorous exercise training on its own, the addition of 5-amino-1MQ conferred sustained enhanced muscle performance, suggesting a reduced need for muscle recovery