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Also, Yohimbine, an 2-adrenergic antagonist that increased the release of norepinephrine (NE), was found to reverse the depressant effect of REM sleep on hypoglossal motoneurons by activating A7 and A5 neurons, which consequently alleviated OSA-induced in rats [28]

Ahuja, P

A recent study has found that IH and SF treatment in mice can regulate hippocampal neuronal apoptosis through Nrf2 [35]

an IV dose runs a few minutes
