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The role of free radicals and antioxidants in reproduction

300 Diabetes Insulin resistance and high blood glucose levels increase oxidative stress, trigger vascular inflammation and endothelial dysfunction, activate platelets and pro-coagulation proteins, and inhibit fibrinolysis

Dear Dona, Frankie, and Jellybean Great question and a very timely one

Glutathione and hallmarks of aging: A study in older adults (n=48, aged 60-80) found that GlyNAC supplementation for 16 weeks improved several molecular hallmarks of aging, including mitophagy, nutrient sensing (reduced mTOR activation, increased AMPK signaling), inflammation (reduced NF-kB activation), and genomic instability (reduced 8-OHdG), alongside increased telomerase activity (Kumar et al., Aging, 2023) [31]
