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Senescent cells contribute through the senescence-associated secretory phenotype (SASP), which involves the sustained secretion of pro-inflammatory mediators such as IL-6 and matrix metalloproteinases (MMPs) 42

Taccori A, Maksoud R, Eaton-Fitch N, Patel M, Marshall-Gradisnik S

A randomized trial published in the European Journal of Pain found that vitamin B12 significantly improved pain scores in patients with chronic low back pain compared to placebo