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J., Cutler R

Secondly, since cardiomyocytes are easily affected by free iron overload, the release of excess free iron during ferroptosis would result in up-regulation of transferrin receptor (TFR) and down-regulation of ferritin, promoting cardiomyocyte cell death through mitochondrial VDAC2/3 or membrane lipid peroxidation through Fenton reaction to induce myocardial edema and dysfunction (Liu et al., 2018)

10.1016/j.neuropharm.2009.10.007 Neuropharmacology 87 RiceM.CraggS

Therefore it is concluded that Hg causes hepatotoxicity 10,76 To estimate the efficacy of wheatgrass extract on HgCl 2 -induced hepatic toxicity, liver function tests were measured after wheatgrass supplementation in the serum of HgCl 2 treated rats