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DOI:10.1128/EC.00297-06 137

Under arsenite stress, this METTL3/YTHDF2 interaction is inhibited, which stabilizes CHAC1 mRNA and increases its expression ( In addition to arsenite-induced expression, the CHAC1 gene is transcriptionally activated during cysteine, serine or arginine depletion (Ward et al., 2024)

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The fragment DNA produced by DSBs can also be sensed by intracellular cGAS, thereby activating STING-TBK1-IRF3 signal to increase the secretion of type I IFN, which is an important way to induce the expression of PD-L1 (68, 69)