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One exception is NKH, whose management initially included the administration of the partial antagonists dextromethorphan or ketamine to reduce seizures, but this has been a matter of debate owing to the lack of clear clinical evidence of therapeutic benefits and to the potential adverse effects of these drugs [122]

elegans (Antebi et al., daf-12 alleles affect aging in distinct ways, depending on whether they cause a complete loss of daf-12 activity or abrogate only specific molecular functions, e.g., the capacity to bind ligands (reviewed in Glikov et al., A Role for NHR Signaling and Fatty Acid Desaturases in Aging Adding to the role for DAF-12 in longevity, a new study reports a key role for another NHR and for one downstream target, a fatty acid desaturase (Goudeau et al., glp-1 mutants, NHR-80 is upregulated, and transgenic NHR-80 overexpression further extends animal life span

Carnitine and chromium co-supplementation affects mental health, hormonal, inflammatory, genetic, and oxidative stress parameters in women with polycystic ovary syndrome

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