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Therefore, the dose may need to be lowered for these patients [102,103]

In general, inflammatory stressors appear to activate an endogenous inhibitory pathway, whereby NO and CO attenuate the stimulated secretion of CRH and AVP

We need to urgently address the underlying drivers of peptide demand, limit online access, and better equip clinicians to identify and respond to peptide use. RACGP Specific Interests Child and Young Persons Health Chair Dr Tim Jones agrees, saying government, regulation and health all need to be involved in a coordinated response, but GPs also need better resources

However, human clinical trials are still limited, and optimal dosing in humans has not been formally established
