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This corrected matrix was then analysed using DESeq2 to calculate the adjusted P value in the covariate model

Current evidence-based NHS treatment focuses on lifestyle modification including weight loss, dietary changes, and increased physical activity, which have the strongest evidence for improving liver health

Frequently Asked Questions Sources Novo Nordisk REDEFINE 1 headline results, December 2024 Novo Nordisk CagriSema US regulatory submission, December 2025 Novo Nordisk REDEFINE 4 headline results, February 2026 Novo Nordisk REIMAGINE 2 headline results, February 2026 Novo Nordisk Annual Report 2025, CagriSema and cagrilintide update Once-weekly cagrilintide dose-finding trial, The Lancet, 2021 Medical Disclaimer: This content is for informational purposes only and is not medical advice