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Depletion of mitochondrial calcium transporters has been shown to mitigate the inflammatory damage caused by glial cells activated by lipopolysaccharides (66)

It has been shown that HTX-3 nanoparticles, a derivative of HTX conjugated to caffeic acid skeletons, can enhance BBB penetration, accelerate metabolism, and prolong brain retention in murine models [96]

[PubMed 6798865] 556

Mechanism of action of St Johns wort in depression: what is known
