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2017;10:147-153 Sitohang IBS, Ninditya S

However, the red cell is not metabolically inert

Immortalization involves modifying somatic cells to enable indefinite selfrenewal by introducing telomerase or altering genes that regulate the cell cycle and prevent telomere shortening (De Bardet et al

In addition to their metabolic roles, key enzymes exert non-metabolic regulatory functions that further promote tumor progression
