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Although bilin chromophores are the primary targets of free radicals, there is evidence that apo-biliproteins also exhibit antioxidant activities (Pleonsil et al

Mitochondria are the main source of intracellular ROS, in which the superoxide produced by the electron leakage of the electron transport chain (ETC) produces hydroxyl radicals through a series of reactions, thus driving PUFA-PL peroxidation

Work from Hei Sook Suls lab demonstrated that PNPLA2 in adipocytes was required to maintain a BAT phenotype through the regulation of PPAR, a nuclear transcription factor (140)

FDA approval and clinical evidence Tesamorelin carries FDA approval under the brand name Egrifta, specifically for reducing excess visceral abdominal fat in HIV-positive patients with lipodystrophy