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Metabolic concerns (central weight gain, low muscle mass) that may improve when testosterone and gonadotropins normalize, as suggested in emerging data

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We are very grateful to Donatella Pascai, Giuseppina Dibenedetto and Martina Ippoliti for their expert organization and performance of blood sampling

Furthermore, heritability estimates range from 30 to 40% (Girgenti et al., 2021) with genome-wide studies implicating immune-linked loci such as ANKRD55 among others (Stein et al., 2016
